Oct 11, 2025
3 min read
Korea's lessons represents the claim last but the relationship is still unbalanced
- Razing Parkinson has become higher in people with leg-footing diseases in the Korea.
- Dopamine Agonist treatment was tied to the risk of smaller parkinson in patients with restless bening syndrome.
- Diagnostic challenges may have influenced the results and interpretation of the study.
Unlastal synthem (RSS) for the diagnosis of Parkininese diagnosis, information from Korean region study.
During the analysis of the analysis of control over cases of Parkinson's disease, 1.0% in the control group and 1.6% among the people with RLS, said Chen Hong Kim, Candidate of Medical Sciences and co -ate -Korean Ansan Hospital, MD and co -authors.
For a predetermined 15 -year period, the limited average survival time (RMST) for the diagnosis of Parkinson's disease is 14.93 years in the control group and 14.88 years in the RLS group, a difference of -0.05 (95% CI -0.07 to -03 years), Kim and colleagues reported in JAM
During the monitoring period, 0.5% of people with RLS with dopamine agonist Parkinson developed, compared to 2.1% in the unspent RLS group.
Is estimated with control of the RLS Groups of Parker Rans (-0.09) for a short period of time).Long distance (differences of age 0.03).
"These findings suggest that the pathophysiological link between restless legs syndrome and Parkinson's disease may include mechanisms beyond the dopaminergic pathway," the researchers said.
RLS is characterized by a desire to move the legs, which is worse at rest and relieves when you move. It can be idiopathic or associated with concomitant diseases such as iron deficiency, chronic kidney disease, polyneuropathy, diabetes, multiple sclerosis and cardiovascular disease.
There are several drugs to treat RLS, but dopamine agonists have noticed the symptoms, especially for the first lines, they noticed KIM and co-authors.
In 2017, the Veterans found almost 3.5 million American studies in the connection between RLS and events in a small number of people.Values showed the risk of RLS to improve the risk of Parkinson's diagnosis, probably due to the progress of the disease.
While the Korean analysis might lend support to prior claims of an increased risk of Parkinson's among people with RLS, alternative explanations "must be strongly considered," emphasized Mark Baron, MD, of the Richmond Veterans Administration Medical Center in Virginia.
The great distance of the subject is to find out where it was accepted without being specific to this hospital, Baron saw inside.
"Information that is not accepted by the verification time or specific sleep.""So, stage of all diseases and cost of all patients and costs of tin
Rapid eye movement (REM) sleep disruption (RBD) is a common feature of Parkinson's disease.and occurs and occurs in 30% to 7% of patients.
"In the RBD, the people on their own people due to the loss of neurological loss that maintains atony (organs) Time of dreams (13).
“Periodic lower extremity sleepiness (PLMS) is a frequent symptom of RLS, found in more than 80% of RLS patients,” he continued.
The Korean study also suggests that exposure to dopaminergic agonist is linked to the lower frequency of Parkinson's disease, but "alternative explanations can also easily contribute to this rush," Baron said.
He also said that the RLS's Genom-Wide Association studies have many non-dopaminegic mechanisms, "he said," on the contrary, this genomic study failed to support the relationship between unhealthy feet syndrome and Parkinson's disease, "he wrote.
Kim and colleagues studied 9,199 patients with RLS and 9,199 identical controls of a Korean national health insurance service from 2002 to 2019. The average age of registration was 50 and 62.8 % of the female sample.
RLS is identified by RLS and Parkinson's ICD.RL Number accompanied by Dopamine Agon
The researchers have recognized the restrictions of their study, including several centers of diagnosis of RLs.
Although this study was investigated before the RLS, "it did not show problems without problems and not sharing a dolse in the middle of the RLS and Parkinson.
